MP24-17 CAN WE BETTER UNDERSTAND PI-RADS 3 LESIONS AND AVOID UNNECESSARY BIOPSIES?

Budget impact model: epigenetic assay can help avoid unnecessary repeated prostate biopsies and reduce healthcare spending.

BACKGROUND The diagnosis of prostate cancer involves invasive, sometimes harmful, procedures that can entail negative quality-of-life implications to individuals and high additional costs to the US healthcare system when these procedures result in retesting and iatrogenic harms. It is estimated that $1.86 billion is spent annually on prostate-specific antigen (PSA) testing alone. An advanced ep...

Lipids in cell biology: how can we understand them better?

Lipids are a major class of biological molecules and play many key roles in different processes. The diversity of lipids is on the same order of magnitude as that of proteins: cells express tens of thousands of different lipids and hundreds of proteins to regulate their metabolism and transport. Despite their clear importance and essential functions, lipids have not been as well studied as prot...

MRI in early prostate cancer detection: how to manage indeterminate or equivocal PI-RADS 3 lesions?

This review focuses on indeterminate lesions on prostate magnetic resonance imaging (MRI), assigned as PI-RADS category 3. The prevalence of PI-RADS 3 index lesion in the diagnostic work-up is significant, varying between one in three (32%) to one in five (22%) men, depending on patient cohort of first biopsies, previously negative biopsies, and active surveillance biopsies. A management strate...

We must--and we can--do better.

Focus on physical activity can help avoid unnecessary social care.

Social care has received substantial media coverage in recent months. There is now acknowledgment of the direct link between the parlous state of the NHS and the social care crisis. Most social and political commentators focus on cuts in public funding of social care, shortages of staff, the increasingly fragile financial state of care home providers, and knock-on consequences for the NHS. The ...